Why you may need to give up beer, sugar and Viagra


 

 

It’s time to give up the fun stuff: beer, all sugar and yes – even Viagra. They may contribute to melanoma.Buzz-and-Woody

There’s an apparent link between Viagra and melanoma. A recent study published in JAMA Internal Medicine followed 25,000 men. They found men who used Viagra had nearly twice the risk of developing melanoma. Men who used it at any time at all faced a similar risk. (There was no risk involved with erectile dysfunction and melanoma, though – just the use of Viagra). Recent sildenafil use was also significantly associated with an increased risk of subsequent melanoma.

While melanoma cases continue to rise dramatically with over 9,000 diagnosed annually in the US alone, some naysayers of the study say there’s no direct link proving Viagra alone is the culprit. The study, while not calling for a change in clinical recommendations, calls for additional research to determine whether there is indeed a link. You can check out the article yourself here:

Did you know Viagra is also used to keep flowers fresh at your florist’s? Check it out here.

There’s also a possible link between beer consumption and melanoma.

 

A spoonful of sugar makes the melanoma go: the role of heparan sulfate proteoglycans in melanoma metastasis.

Heparan sulfate proteoglycans (HSPGs) have been shown to regulate signaling in many systems and are of increasing interest in cancer. While these are not the only sugars to drive melanoma metastasis, HSPGs play important roles in driving metastatic signaling cascades in melanoma. The ability of these proteins to modulate ligand-receptor interactions in melanoma has been quite understudied. Recent data from several groups indicate the importance of these ligands in modulating key signaling pathways including Wnt and fibroblast growth factor (FGF) signaling. In this review, we summarize the current knowledge regarding the structure and function of these proteoglycans and their role in melanoma. Understanding how HSPGs modulate signaling in melanoma could lead to new therapeutic approaches via the dampening or heightening of key signaling pathways.

The article snippet above was copied from Pubmed. Read the rest by clicking here:

 

 

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