Viagra, Sildenafil and cancer


Pfizer is jumping for joy. Not only did they successfully renew their patent and are still charging about $30 per pill, there are many possible great things Viagra can do – including help cure cancer while contributing to a great date night.

Have you noticed that most men think sex cures everything? As it turns out, they may be right – at least indirectly. As it turns out, the chemistry that makes sex happen might possibly cure many things – or at least play a role in doing so.

While still in clinical trials for various cancer types, what they’re finding is that Viagra basically ‘pulls the mask’ off of cancer cells, allowing your body to correctly identify the cancer for what it is: a good cell gone bad that needs to go. Without this phenomena cancer cells emit chemicals which trick your body into thinking everything is okay. Think of it like the ultimate zombie war: cancer cells were healthy cells and may be again, but don’t act like them.

For the sake of science and cancer help, I’ll tell you this awkward story. The day after Kevin has his punch biopsy for melanoma on his scalp, he took 1/2 pill of Viagra. The site of the punch biopsy began throbbing and hurting immensely. Concerned, I immediately looked up what side effects Viagra might have on cancer, and found a whole lot of good information.

As it turned out, the pain and throbbing in his scalp were probably very good signs – it showed the his body finally recognized there was a problem, and sent white blood cells to take care of it. We allocated our tightly budgeted money to Viagra, and cleared it with his oncologist in case Kevin was accepted for clinical trials if things got worse. But things didn’t get worse. With melanoma, at the time there were no other good recourses, so Viagra seemed like the best thing we could do.

While the melanoma was confirmed and appeared to offer a poor prognosis (according to depth, location and size) remarkably it had not spread. I often wonder if this is because of Viagra, and very careful eating.

Here are more articles about Viagra to help with your cancer research:

Viagra can help treat heart and lung conditions

Viagra okay’d to treat pulmonary hypertension

Viagra can help those with pulmonary fibrosis (2010)

Viagra or Levitra can help reduce brain cancer tumors by allowing greater amoutns of Herceptin to pass the blood-brain barrier

Viagra helps boost anti-tumor effects of doxorubicin in human prostate cancers (it can also help with Crohn’s diseas)

A full paper on the role of Sildenafil (Viagra) and cancers
The condensed version: The role of Viagra is possibly this: increased PDE5 occurs in several human carcinomas, such as bladder cancer, breast cancer and non-small cell lung cancer. Inhibiting PDE5 is one of the things that Viagra does. It’s showing promise when combined with chemotherapy. It can also reverse tumor-induced immunosuppression and can delay tumor growth for certain cancers.

Cited papers include:

Twentyman PR, Fox NE, White DJ. Cyclosporin A and its analogues as
modifiers of adriamycin and vincristine resistance in a multi-drug
resistant human lung cancer cell line. Br J Cancer 1987;56:55–7.

Whitehead CM, Earle KA, Fetter J, Xu S, Hartman T, Chan DC, et al.
Exisulind-induced apoptosis in a non-small cell lung cancer
orthotopic lung tumor model augments docetaxel treatment and
contributes to increased survival. Mol Cancer Ther 2003;2:479–88.

Incidentally, want to make your own Viagra? Here’s the recipe:

Steps In Making Viagra

  1. Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate
  2. Hydrolysis with aqueous NaOH to free acid
  3. Nitration with oleum/fuming nitric acid
  4. Carboxamide formation with refluxing thionyl chloride/NH4OH
  5. Reduction of nitro group to amino
  6. Acylation with 2-ethoxybenzoyl chloride
  7. Cyclization
  8. Sulfonation to the chlorosulfonyl derivative
  9. Condensation with 1-methylpiperazine

Empirical formula = C22H30N6O4S
molecular weight = 474.5
solubility = 3.5 mg/mL in water

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One thought on “Viagra, Sildenafil and cancer

  1. Pingback: New Anti-PD-1 melanoma clinical trial & a smarter way to provide radiotherapy | parentsof10

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